RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

Proliferative chronic myelomonocytic leukemia (pCMML), an aggressive CMML subtype, is associated with dismal outcomes. RAS pathway mutations, mainly NRAS(G12D), define the pCMML phenotype as demonstrated by our exome sequencing, progenitor colony assays and a Vav-Cre-Nras(G12D) mouse model. Further,...

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Detalles Bibliográficos
Autores principales: Carr, Ryan M., Vorobyev, Denis, Lasho, Terra, Marks, David L., Tolosa, Ezequiel J., Vedder, Alexis, Almada, Luciana L., Yurcheko, Andrey, Padioleau, Ismael, Alver, Bonnie, Coltro, Giacomo, Binder, Moritz, Safgren, Stephanie L., Horn, Isaac, You, Xiaona, Solary, Eric, Balasis, Maria E., Berger, Kurt, Hiebert, James, Witzig, Thomas, Buradkar, Ajinkya, Graf, Temeida, Valent, Peter, Mangaonkar, Abhishek A., Robertson, Keith D., Howard, Matthew T., Kaufmann, Scott H., Pin, Christopher, Fernandez-Zapico, Martin E., Geissler, Klaus, Droin, Nathalie, Padron, Eric, Zhang, Jing, Nikolaev, Sergey, Patnaik, Mrinal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131698/
https://www.ncbi.nlm.nih.gov/pubmed/34006870
http://dx.doi.org/10.1038/s41467-021-23186-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131698/
https://www.ncbi.nlm.nih.gov/pubmed/34006870
http://dx.doi.org/10.1038/s41467-021-23186-w

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