Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs

Small interfering RNA (siRNA) is an effective therapeutic to regulate the expression of target genes in vitro and in vivo. Constructing a siRNA delivery system with high serum stability, especially responsive to endogenous stimuli, remains technically challenging. Herein we develop anti-degradation...

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Detalles Bibliográficos
Autores principales: Xue, Chang, Hu, Shuyao, Gao, Zhi-Hua, Wang, Lei, Luo, Meng-Xue, Yu, Xin, Li, Bi-Fei, Shen, Zhifa, Wu, Zai-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131747/
https://www.ncbi.nlm.nih.gov/pubmed/34006888
http://dx.doi.org/10.1038/s41467-021-23250-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131747/
https://www.ncbi.nlm.nih.gov/pubmed/34006888
http://dx.doi.org/10.1038/s41467-021-23250-5

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