From multi-omics integration towards novel genomic interaction networks to identify key cancer cell line characteristics

Cancer is a complex disease where cancer cells express epigenetic and transcriptomic mechanisms to promote tumor initiation, progression, and survival. To extract relevant features from the 2019 Cancer Cell Line Encyclopedia (CCLE), a multi-layer nonnegative matrix factorization approach is used. We...

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Detalles Bibliográficos
Autores principales: Kuijpers, T. J. M., Kleinjans, J. C. S., Jennen, D. G. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131752/
https://www.ncbi.nlm.nih.gov/pubmed/34006939
http://dx.doi.org/10.1038/s41598-021-90047-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131752/
https://www.ncbi.nlm.nih.gov/pubmed/34006939
http://dx.doi.org/10.1038/s41598-021-90047-3

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