Machine learning reveals hidden stability code in protein native fluorescence

Conformational stability of a protein is usually obtained by spectroscopically measuring the unfolding melting temperature. However, optical spectra under native conditions are considered to contain too little resolution to probe protein stability. Here, we have built and trained a neural network mo...

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Detalles Bibliográficos
Autores principales: Zhang, Hongyu, Yang, Yang, Zhang, Cheng, Farid, Suzanne S., Dalby, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131987/
https://www.ncbi.nlm.nih.gov/pubmed/34093990
http://dx.doi.org/10.1016/j.csbj.2021.04.047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131987/
https://www.ncbi.nlm.nih.gov/pubmed/34093990
http://dx.doi.org/10.1016/j.csbj.2021.04.047

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