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Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19
Secondary bacterial infections, including ventilator-associated pneumonia (VAP), lead to worse clinical outcomes and increased mortality following viral respiratory infections including in patients with coronavirus disease 2019 (COVID-19). Using a combination of tracheal aspirate bulk and single-cel...
Autores principales: | Tsitsiklis, Alexandra, Zha, Beth Shoshana, Byrne, Ashley, Devoe, Catherine, Levan, Sophia, Rackaityte, Elze, Sunshine, Sara, Mick, Eran, Ghale, Rajani, Jauregui, Alejandra, Sarma, Aartik, Neff, Norma, Serpa, Paula Hayakawa, Deiss, Thomas J., Kistler, Amy, Carrillo, Sidney, Ansel, K. Mark, Leligdowicz, Aleksandra, Christenson, Stephanie, Jones, Norman, Wu, Bing, Darmanis, Spyros, Matthay, Michael A., Lynch, Susan V., DeRisi, Joseph L., Hendrickson, Carolyn M., Kangelaris, Kirsten N., Krummel, Matthew F., Woodruff, Prescott G., Erle, David J., Rosenberg, Oren, Calfee, Carolyn S., Langelier, Charles R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132240/ https://www.ncbi.nlm.nih.gov/pubmed/34013247 http://dx.doi.org/10.21203/rs.3.rs-380803/v1 |
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