Novel mechanism for OSM-promoted extracellular matrix remodeling in breast cancer: LOXL2 upregulation and subsequent ECM alignment

BACKGROUND: Invasive ductal carcinoma (IDC) is a serious problem for patients as it metastasizes, decreasing 5-year patient survival from > 95 to ~ 27%. The breast tumor microenvironment (TME) is often saturated with proinflammatory cytokines, such as oncostatin M (OSM), which promote epithelial-...

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Detalles Bibliográficos
Autores principales: Dinca, Simion C., Greiner, Daniel, Weidenfeld, Keren, Bond, Laura, Barkan, Dalit, Jorcyk, Cheryl L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132418/
https://www.ncbi.nlm.nih.gov/pubmed/34011405
http://dx.doi.org/10.1186/s13058-021-01430-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132418/
https://www.ncbi.nlm.nih.gov/pubmed/34011405
http://dx.doi.org/10.1186/s13058-021-01430-x

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