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Investigating the impact of reference assembly choice on genomic analyses in a cattle breed
BACKGROUND: Reference-guided read alignment and variant genotyping are prone to reference allele bias, particularly for samples that are greatly divergent from the reference genome. A Hereford-based assembly is the widely accepted bovine reference genome. Haplotype-resolved genomes that exceed the c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132449/ https://www.ncbi.nlm.nih.gov/pubmed/34011274 http://dx.doi.org/10.1186/s12864-021-07554-w |