First genome-wide association study on rocuronium dose requirements shows association with SLCO1A2

BACKGROUND: Rocuronium, a common neuromuscular blocking agent, is mainly excreted unchanged in urine (10–25%) and bile (>70%). Age, sex, liver blood flow, smoking, medical conditions, and ethnic background can affect its pharmacological actions. However, reasons for the wide variation in rocuroni...

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Detalles Bibliográficos
Autores principales: Ahlström, Sirkku, Bergman, Paula, Jokela, Ritva, Ottensmann, Linda, Ahola-Olli, Ari, Pirinen, Matti, Olkkola, Klaus T., Kaunisto, Mari A., Kalso, Eija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Clinical Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132880/
https://www.ncbi.nlm.nih.gov/pubmed/33676726
http://dx.doi.org/10.1016/j.bja.2021.01.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132880/
https://www.ncbi.nlm.nih.gov/pubmed/33676726
http://dx.doi.org/10.1016/j.bja.2021.01.029

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