Linchpins empower promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins

The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chemical space to enable site-selectivity for histid...

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Detalles Bibliográficos
Autores principales: Rawale, Dattatraya Gautam, Thakur, Kalyani, Sreekumar, Pranav, T. K., Sajeev, A., Ramesh, Adusumalli, Srinivasa Rao, Mishra, Ram Kumar, Rai, Vishal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133000/
https://www.ncbi.nlm.nih.gov/pubmed/34040749
http://dx.doi.org/10.1039/d1sc00335f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133000/
https://www.ncbi.nlm.nih.gov/pubmed/34040749
http://dx.doi.org/10.1039/d1sc00335f

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