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Reduced purine biosynthesis in humans after their divergence from Neandertals
We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other primates, metabolites downstream of adenylosuccin...
Autores principales: | Stepanova, Vita, Moczulska, Kaja Ewa, Vacano, Guido N, Kurochkin, Ilia, Ju, Xiangchun, Riesenberg, Stephan, Macak, Dominik, Maricic, Tomislav, Dombrowski, Linda, Schörnig, Maria, Anastassiadis, Konstantinos, Baker, Oliver, Naumann, Ronald, Khrameeva, Ekaterina, Vanushkina, Anna, Stekolshchikova, Elena, Egorova, Alina, Tkachev, Anna, Mazzarino, Randall, Duval, Nathan, Zubkov, Dmitri, Giavalisco, Patrick, Wilkinson, Terry G, Patterson, David, Khaitovich, Philipp, Pääbo, Svante |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133780/ https://www.ncbi.nlm.nih.gov/pubmed/33942714 http://dx.doi.org/10.7554/eLife.58741 |
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