Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis

Transcriptional silencing of the FMR1 gene in fragile X syndrome (FXS) leads to the loss of the RNA-binding protein FMRP. In addition to regulating mRNA translation and protein synthesis, emerging evidence suggests that FMRP acts to coordinate proliferation and differentiation during early neural de...

Descripción completa

Detalles Bibliográficos
Autores principales: Raj, Nisha, McEachin, Zachary T., Harousseau, William, Zhou, Ying, Zhang, Feiran, Merritt-Garza, Megan E., Taliaferro, J. Matthew, Kalinowska, Magdalena, Marro, Samuele G., Hales, Chadwick M., Berry-Kravis, Elizabeth, Wolf-Ochoa, Marisol W., Martinez-Cerdeño, Veronica, Wernig, Marius, Chen, Lu, Klann, Eric, Warren, Stephen T., Jin, Peng, Wen, Zhexing, Bassell, Gary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133829/
https://www.ncbi.nlm.nih.gov/pubmed/33852833
http://dx.doi.org/10.1016/j.celrep.2021.108991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133829/
https://www.ncbi.nlm.nih.gov/pubmed/33852833
http://dx.doi.org/10.1016/j.celrep.2021.108991

Ejemplares similares