Cargando…

MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner

MRE11, the nuclease component of RAD50/MRE11/NBS1 DNA repair complex which is essential for repair of DNA double-strand-breaks in normal cells, has recently garnered attention as a critical factor in solid tumor development. Herein we report the crucial role of MRE11 in oral cancer progression in a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yen-Yun, Chen, Yuk-Kwan, Lo, Steven, Chi, Tsung-Chen, Chen, Yi-Hua, Hu, Stephen Chu-Sung, Chen, Ya-Wen, Jiang, Shih Sheng, Tsai, Fang-Yu, Liu, Wangta, Li, Ruei-Nian, Hsieh, Ya-Ching, Huang, Chih-Jen, Yuan, Shyng-Shiou F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134045/ https://www.ncbi.nlm.nih.gov/pubmed/33927349 http://dx.doi.org/10.1038/s41388-021-01698-5

Ejemplares similares

CD44 Mediates Oral Squamous Cell Carcinoma-Promoting Activity of MRE11 via AKT Signaling
por: Yuan, Shyng-Shiou F., et al.
Publicado: (2022)

The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition
por: Thompson, Ruth, et al.
Publicado: (2012)

Formation of Linear Amplicons with Inverted Duplications in Leishmania Requires the MRE11 Nuclease
por: Laffitte, Marie-Claude N., et al.
Publicado: (2014)

Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses
por: Yang, Cheng-Hong, et al.
Publicado: (2017)

Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles
por: Wang, Weibin, et al.
Publicado: (2017)

CD44 Promotes Breast Cancer Metastasis through AKT-Mediated Downregulation of Nuclear FOXA2
por: Vadhan, Anupama, et al.
Publicado: (2022)

Interplay of Mre11 Nuclease with Dna2 plus Sgs1 in Rad51-Dependent Recombinational Repair
por: Budd, Martin E., et al.
Publicado: (2009)

Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing
por: Carvajal-Maldonado, Denisse, et al.
Publicado: (2019)

SIRT1 Mediates FOXA2 Breakdown by Deacetylation in a Nutrient-Dependent Manner
por: van Gent, Rogier, et al.
Publicado: (2014)

A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex
por: Lim, Chew Theng, et al.
Publicado: (2015)

Identification of Plasmodium falciparum DNA Repair Protein Mre11 with an Evolutionarily Conserved Nuclease Function
por: Badugu, Sugith Babu, et al.
Publicado: (2015)

Foxa1 and Foxa2 Are Required for Formation of the Intervertebral Discs
por: Maier, Jennifer A., et al.
Publicado: (2013)

RUNX2 and Cancer
por: Lin, Tsung-Chieh
Publicado: (2023)

Correction: Identification of Plasmodium falciparum DNA Repair Protein Mre11 with an Evolutionarily Conserved Nuclease Function
por: Badugu, Sugith Babu, et al.
Publicado: (2023)

Physiological protein blocks direct the Mre11–Rad50–Xrs2 and Sae2 nuclease complex to initiate DNA end resection
por: Reginato, Giordano, et al.
Publicado: (2017)

The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair
por: Liao, Shuren, et al.
Publicado: (2016)

Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages
por: Wang, Yen-Yun, et al.
Publicado: (2020)

ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model
por: Wang, Yen-Yun, et al.
Publicado: (2022)

RUNX1-ETO (RUNX1-RUNX1T1) induces myeloid leukemia in mice in an age-dependent manner
por: Abdallah, Mohamed Gaber, et al.
Publicado: (2021)

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
por: Lemaçon, Delphine, et al.
Publicado: (2017)

Overexpression of sprouty 1 protein in human oral squamous cell carcinogenesis
por: Wang, Yen-Yun, et al.
Publicado: (2021)

Expression of Orai1 and STIM1 in human oral squamous cell carcinogenesis
por: Wang, Yen-Yun, et al.
Publicado: (2022)

Overexpression of transient receptor potential melastatin 6 during human oral squamous cell carcinogenesis
por: Wang, Yen-Yun, et al.
Publicado: (2023)

Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases
por: Hale, Anastasia, et al.
Publicado: (2023)

Excision repair cross-complementing group 2 upregulation is a potential predictive biomarker for oral squamous cell carcinoma recurrence
por: Wang, Yen-Yun, et al.
Publicado: (2021)

Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance
por: Domanskyi, Andrii, et al.
Publicado: (2014)

S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex
por: Chen, Yu-Jie, et al.
Publicado: (2016)

Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-Nuclease
por: Westmoreland, James W., et al.
Publicado: (2013)

MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA
por: Liu, Xiaolong, et al.
Publicado: (2020)

The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH
por: Wang, Ranran, et al.
Publicado: (2015)

The Role of MreB, MreC and MreD in the Morphology of the Diazotrophic Filament of Anabaena sp. PCC 7120
por: Velázquez-Suárez, Cristina, et al.
Publicado: (2022)

Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner
por: Zheng, Lihua, et al.
Publicado: (2007)

The bacterial Mre11–Rad50 homolog SbcCD cleaves opposing strands of DNA by two chemically distinct nuclease reactions
por: Saathoff, Jan-Hinnerk, et al.
Publicado: (2018)

MreC and MreD Proteins Are Not Required for Growth of Staphylococcus aureus
por: Tavares, Andreia C., et al.
Publicado: (2015)

Ristretto MRE: A generalized multi‐shot GRE‐MRE sequence
por: Guenthner, Christian, et al.
Publicado: (2019)

FoXA2 promotes esophageal squamous cell carcinoma progression by ZEB2 activation
por: Gao, Hanjing, et al.
Publicado: (2021)

Orabase-Formulated Benzalkonium Chloride Effectively Suppressed Oral Potentially Malignant Disorder In Vitro and In Vivo
por: Wang, Yen-Yun, et al.
Publicado: (2020)

Genome-Wide Location Analysis Reveals Distinct Transcriptional Circuitry by Paralogous Regulators Foxa1 and Foxa2
por: Bochkis, Irina M., et al.
Publicado: (2012)

Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells
por: Whirledge, Shannon, et al.
Publicado: (2017)

Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation
por: Lau, Ching-In, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9ckjtg2qcnn1nnl9h4q8r55mv0