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MMP20-generated amelogenin cleavage products prevent formation of fan-shaped enamel malformations

Dental enamel forms extracellularly as thin ribbons of amorphous calcium phosphate (ACP) that initiate on dentin mineral in close proximity to the ameloblast distal membrane. Secreted proteins are critical for this process. Enam(−/−) and Ambn(−/−) mice fail to form enamel. We characterize enamel rib...

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Detalles Bibliográficos
Autores principales: Bartlett, John D., Smith, Charles E., Hu, Yuanyuan, Ikeda, Atsushi, Strauss, Mike, Liang, Tian, Hsu, Ya-Hsiang, Trout, Amanda H., McComb, David W., Freeman, Rebecca C., Simmer, James P., Hu, Jan C.-C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134442/
https://www.ncbi.nlm.nih.gov/pubmed/34012043
http://dx.doi.org/10.1038/s41598-021-90005-z