Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

Placental malaria can have severe consequences for both mother and child and effective vaccines are lacking. Parasite-infected red blood cells sequester in the placenta through interaction between parasite-expressed protein VAR2CSA and the glycosaminoglycan chondroitin sulfate A (CS) abundantly pres...

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Detalles Bibliográficos
Autores principales: Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, Sandeep K., Spliid, Charlotte B., Wang, Yong, Gustavsson, Tobias, Sandoval, Daniel R., Vidal-Calvo, Elena Ethel, Choudhary, Swati, Agerbaek, Mette Ø, Lindorff-Larsen, Kresten, Nielsen, Morten A., Theander, Thor G., Sharp, Joshua S., Clausen, Thomas Mandel, Gourdon, Pontus, Salanti, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134449/
https://www.ncbi.nlm.nih.gov/pubmed/34011972
http://dx.doi.org/10.1038/s41467-021-23254-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134449/
https://www.ncbi.nlm.nih.gov/pubmed/34011972
http://dx.doi.org/10.1038/s41467-021-23254-1

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