DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift

Culture expansion of primary cells evokes highly reproducible DNA methylation (DNAm) changes. We have identified CG dinucleotides (CpGs) that become continuously hyper- or hypomethylated during long-term culture of mesenchymal stem cells (MSCs) and other cell types. Bisulfite barcoded amplicon seque...

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Detalles Bibliográficos
Autores principales: Franzen, Julia, Georgomanolis, Theodoros, Selich, Anton, Kuo, Chao-Chung, Stöger, Reinhard, Brant, Lilija, Mulabdić, Melita Sara, Fernandez-Rebollo, Eduardo, Grezella, Clara, Ostrowska, Alina, Begemann, Matthias, Nikolić, Miloš, Rath, Björn, Ho, Anthony D., Rothe, Michael, Schambach, Axel, Papantonis, Argyris, Wagner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134454/
https://www.ncbi.nlm.nih.gov/pubmed/34011964
http://dx.doi.org/10.1038/s42003-021-02116-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134454/
https://www.ncbi.nlm.nih.gov/pubmed/34011964
http://dx.doi.org/10.1038/s42003-021-02116-y

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