A trimethoprim derivative impedes antibiotic resistance evolution

The antibiotic trimethoprim (TMP) is used to treat a variety of Escherichia coli infections, but its efficacy is limited by the rapid emergence of TMP-resistant bacteria. Previous laboratory evolution experiments have identified resistance-conferring mutations in the gene encoding the TMP target, ba...

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Detalles Bibliográficos
Autores principales: Manna, Madhu Sudan, Tamer, Yusuf Talha, Gaszek, Ilona, Poulides, Nicole, Ahmed, Ayesha, Wang, Xiaoyu, Toprak, Furkan C. R., Woodard, DaNae R., Koh, Andrew Y., Williams, Noelle S., Borek, Dominika, Atilgan, Ali Rana, Hulleman, John D., Atilgan, Canan, Tambar, Uttam, Toprak, Erdal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134463/
https://www.ncbi.nlm.nih.gov/pubmed/34011959
http://dx.doi.org/10.1038/s41467-021-23191-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134463/
https://www.ncbi.nlm.nih.gov/pubmed/34011959
http://dx.doi.org/10.1038/s41467-021-23191-z

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