BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

Elucidation of non-canonical protein functions can identify novel tissue homeostasis pathways. Herein, we describe a role for the Bcl-2 family member BAD in postnatal mammary gland morphogenesis. In Bad(3SA) knock-in mice, where BAD cannot undergo phosphorylation at 3 key serine residues, pubertal g...

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Detalles Bibliográficos
Autores principales: Githaka, John Maringa, Tripathi, Namita, Kirschenman, Raven, Patel, Namrata, Pandya, Vrajesh, Kramer, David A., Montpetit, Rachel, Zhu, Lin Fu, Sonenberg, Nahum, Fahlman, Richard P., Danial, Nika N., Underhill, D. Alan, Goping, Ing Swie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134504/
https://www.ncbi.nlm.nih.gov/pubmed/34011960
http://dx.doi.org/10.1038/s41467-021-23269-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134504/
https://www.ncbi.nlm.nih.gov/pubmed/34011960
http://dx.doi.org/10.1038/s41467-021-23269-8

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