MIF is a 3’ flap nuclease that facilitates DNA replication and promotes tumor growth

How cancer cells cope with high levels of replication stress during rapid proliferation is currently unclear. Here, we show that macrophage migration inhibitory factor (MIF) is a 3’ flap nuclease that translocates to the nucleus in S phase. Poly(ADP-ribose) polymerase 1 co-localizes with MIF to the...

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Detalles Bibliográficos
Autores principales: Wang, Yijie, Chen, Yan, Wang, Chenliang, Yang, Mingming, Wang, Yanan, Bao, Lei, Wang, Jennifer E., Kim, BongWoo, Chan, Kara Y., Xu, Weizhi, Capota, Emanuela, Ortega, Janice, Nijhawan, Deepak, Li, Guo-Min, Luo, Weibo, Wang, Yingfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134555/
https://www.ncbi.nlm.nih.gov/pubmed/34012010
http://dx.doi.org/10.1038/s41467-021-23264-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134555/
https://www.ncbi.nlm.nih.gov/pubmed/34012010
http://dx.doi.org/10.1038/s41467-021-23264-z

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