Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin

Recent cryo-EM structures show the highly dynamic nature of the MLL1-NCP (nucleosome core particle) interaction. Functional implication and regulation of such dynamics remain unclear. Here we show that DPY30 and the intrinsically disordered regions (IDRs) of ASH2L work together in restricting the ro...

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Detalles Bibliográficos
Autores principales: Lee, Young-Tae, Ayoub, Alex, Park, Sang-Ho, Sha, Liang, Xu, Jing, Mao, Fengbiao, Zheng, Wei, Zhang, Yang, Cho, Uhn-Soo, Dou, Yali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134635/
https://www.ncbi.nlm.nih.gov/pubmed/34012049
http://dx.doi.org/10.1038/s41467-021-23268-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134635/
https://www.ncbi.nlm.nih.gov/pubmed/34012049
http://dx.doi.org/10.1038/s41467-021-23268-9

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