Proteasome Inhibition Suppresses KIT-Independent Gastrointestinal Stromal Tumors Via Targeting Hippo/YAP/Cyclin D1 Signaling

Purpose: Gastrointestinal stromal tumors (GISTs) are the most common malignant tumor of mesenchymal origin of the digestive tract. A yet more challenging resistance mechanism involves transition from oncogenic KIT to a new imatinib-insensitive oncogenic driver, heralded by loss of KIT expression. Ou...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Ting, Ni, Nan, Yuan, Li, Xu, Liangliang, Bahri, Nacef, Sun, Boshu, Wu, Yuehong, Ou, Wen-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134732/
https://www.ncbi.nlm.nih.gov/pubmed/34025442
http://dx.doi.org/10.3389/fphar.2021.686874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134732/
https://www.ncbi.nlm.nih.gov/pubmed/34025442
http://dx.doi.org/10.3389/fphar.2021.686874

Ejemplares similares