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Proteasome Inhibition Suppresses KIT-Independent Gastrointestinal Stromal Tumors Via Targeting Hippo/YAP/Cyclin D1 Signaling

Purpose: Gastrointestinal stromal tumors (GISTs) are the most common malignant tumor of mesenchymal origin of the digestive tract. A yet more challenging resistance mechanism involves transition from oncogenic KIT to a new imatinib-insensitive oncogenic driver, heralded by loss of KIT expression. Ou...

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Detalles Bibliográficos
Autores principales:	Chen, Ting, Ni, Nan, Yuan, Li, Xu, Liangliang, Bahri, Nacef, Sun, Boshu, Wu, Yuehong, Ou, Wen-Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134732/ https://www.ncbi.nlm.nih.gov/pubmed/34025442 http://dx.doi.org/10.3389/fphar.2021.686874

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