Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis

We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can be upregulated by inflamm...

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Autores principales: Moris, Wenke, Verhaegh, Pauline L. M., Masclee, Ad A. M., Swinkels, Dorine W., Laarakkers, Coby M., Koek, Ger H., van Deursen, Cees Th. B. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134951/
https://www.ncbi.nlm.nih.gov/pubmed/34026154
http://dx.doi.org/10.1002/ccr3.4114
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author Moris, Wenke
Verhaegh, Pauline L. M.
Masclee, Ad A. M.
Swinkels, Dorine W.
Laarakkers, Coby M.
Koek, Ger H.
van Deursen, Cees Th. B. M.
author_facet Moris, Wenke
Verhaegh, Pauline L. M.
Masclee, Ad A. M.
Swinkels, Dorine W.
Laarakkers, Coby M.
Koek, Ger H.
van Deursen, Cees Th. B. M.
author_sort Moris, Wenke
collection PubMed
description We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can be upregulated by inflammation, probably via the JAK/STAT3 pathway.
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spelling pubmed-81349512021-05-21 Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis Moris, Wenke Verhaegh, Pauline L. M. Masclee, Ad A. M. Swinkels, Dorine W. Laarakkers, Coby M. Koek, Ger H. van Deursen, Cees Th. B. M. Clin Case Rep Case Reports We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can be upregulated by inflammation, probably via the JAK/STAT3 pathway. John Wiley and Sons Inc. 2021-05-20 /pmc/articles/PMC8134951/ /pubmed/34026154 http://dx.doi.org/10.1002/ccr3.4114 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Moris, Wenke
Verhaegh, Pauline L. M.
Masclee, Ad A. M.
Swinkels, Dorine W.
Laarakkers, Coby M.
Koek, Ger H.
van Deursen, Cees Th. B. M.
Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis
title Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis
title_full Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis
title_fullStr Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis
title_full_unstemmed Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis
title_short Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis
title_sort inflammation can increase hepcidin in hfe‐hereditary hemochromatosis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134951/
https://www.ncbi.nlm.nih.gov/pubmed/34026154
http://dx.doi.org/10.1002/ccr3.4114
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