“Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation

All neurodegenerative diseases feature aggregates, which usually contain disease‐specific diagnostic proteins; non‐protein constituents, however, have rarely been explored. Aggregates from SY5Y‐APP(Sw) neuroblastoma, a cell model of familial Alzheimer's disease, were crosslinked and sequences o...

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Detalles Bibliográficos
Autores principales: Shmookler Reis, Robert J., Atluri, Ramani, Balasubramaniam, Meenakshisundaram, Johnson, Jay, Ganne, Akshatha, Ayyadevara, Srinivas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135009/
https://www.ncbi.nlm.nih.gov/pubmed/33788386
http://dx.doi.org/10.1111/acel.13326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135009/
https://www.ncbi.nlm.nih.gov/pubmed/33788386
http://dx.doi.org/10.1111/acel.13326

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