Poly(ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions

The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have been identified, how KDM5A recognizes DNA lesion sites within chromatin is unknown. Here, we identify two factors that act upstr...

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Detalles Bibliográficos
Autores principales: Kumbhar, Ramhari, Sanchez, Anthony, Perren, Jullian, Gong, Fade, Corujo, David, Medina, Frank, Devanathan, Sravan K., Xhemalce, Blerta, Matouschek, Andreas, Buschbeck, Marcus, Buck-Koehntop, Bethany A., Miller, Kyle M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135068/
https://www.ncbi.nlm.nih.gov/pubmed/34003252
http://dx.doi.org/10.1083/jcb.202006149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135068/
https://www.ncbi.nlm.nih.gov/pubmed/34003252
http://dx.doi.org/10.1083/jcb.202006149

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