A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria

BACKGROUND: For uncomplicated Plasmodium falciparum malaria, highly efficacious single-dose treatments are expected to increase compliance and improve treatment outcomes, and thereby may slow the development of resistance. The efficacy and safety of a single-dose combination of artefenomel (800 mg)...

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Detalles Bibliográficos
Autores principales: Adoke, Yeka, Zoleko-Manego, Rella, Ouoba, Serge, Tiono, Alfred B., Kaguthi, Grace, Bonzela, Juvêncio Eduardo, Duong, Tran Thanh, Nahum, Alain, Bouyou-Akotet, Marielle, Ogutu, Bernhards, Ouedraogo, Alphonse, Macintyre, Fiona, Jessel, Andreas, Laurijssens, Bart, Cherkaoui-Rbati, Mohammed H., Cantalloube, Cathy, Marrast, Anne Claire, Bejuit, Raphaël, White, David, Wells, Timothy N. C., Wartha, Florian, Leroy, Didier, Kibuuka, Afizi, Mombo-Ngoma, Ghyslain, Ouattara, Daouda, Mugenya, Irène, Phuc, Bui Quang, Bohissou, Francis, Mawili-Mboumba, Denise P., Olewe, Fredrick, Soulama, Issiaka, Tinto, Halidou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135182/
https://www.ncbi.nlm.nih.gov/pubmed/34011358
http://dx.doi.org/10.1186/s12936-021-03749-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135182/
https://www.ncbi.nlm.nih.gov/pubmed/34011358
http://dx.doi.org/10.1186/s12936-021-03749-4

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