β-d-N(4)-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells

Mutagenic ribonucleosides can act as broad-based antiviral agents. They are metabolized to the active ribonucleoside triphosphate form and concentrate in genomes of RNA viruses during viral replication. β-d-N(4)-hydroxycytidine (NHC, initial metabolite of molnupiravir) is >100-fold more active th...

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Detalles Bibliográficos
Autores principales: Zhou, Shuntai, Hill, Collin S, Sarkar, Sanjay, Tse, Longping V, Woodburn, Blaide M D, Schinazi, Raymond F, Sheahan, Timothy P, Baric, Ralph S, Heise, Mark T, Swanstrom, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136050/
https://www.ncbi.nlm.nih.gov/pubmed/33961695
http://dx.doi.org/10.1093/infdis/jiab247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136050/
https://www.ncbi.nlm.nih.gov/pubmed/33961695
http://dx.doi.org/10.1093/infdis/jiab247

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