Cargando…

β-d-N(4)-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells

Mutagenic ribonucleosides can act as broad-based antiviral agents. They are metabolized to the active ribonucleoside triphosphate form and concentrate in genomes of RNA viruses during viral replication. β-d-N(4)-hydroxycytidine (NHC, initial metabolite of molnupiravir) is >100-fold more active th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Shuntai, Hill, Collin S, Sarkar, Sanjay, Tse, Longping V, Woodburn, Blaide M D, Schinazi, Raymond F, Sheahan, Timothy P, Baric, Ralph S, Heise, Mark T, Swanstrom, Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Major Articles and Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136050/ https://www.ncbi.nlm.nih.gov/pubmed/33961695 http://dx.doi.org/10.1093/infdis/jiab247

Ejemplares similares

Reply to Troth et al
por: Zhou, Shuntai, et al.
Publicado: (2021)

Characterization of Macrophage-Tropic HIV-1 Infection of Central Nervous System Cells and the Influence of Inflammation
por: Woodburn, Blaide M., et al.
Publicado: (2022)

Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity
por: Hadj Hassine, Ikbel, et al.
Publicado: (2022)

N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody
por: Zibat, Arne, et al.
Publicado: (2023)

Extinction of Zika Virus and Usutu Virus by Lethal Mutagenesis Reveals Different Patterns of Sensitivity to Three Mutagenic Drugs
por: Bassi, Maria Rosaria, et al.
Publicado: (2018)

Serum Immunoglobulin A Cross-Strain Blockade of Human Noroviruses
por: Lindesmith, Lisa C., et al.
Publicado: (2015)

Small-Molecule Antiviral β-d-N(4)-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance
por: Agostini, Maria L., et al.
Publicado: (2019)

MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV
por: Sheahan, Timothy, et al.
Publicado: (2008)

Could chlorophyllins improve the safety profile of beta-d-N4-hydroxycytidine versus N-hydroxycytidine, the active ingredient of the SARS-CoV-2 antiviral molnupiravir?
por: Clark, Nicole F., et al.
Publicado: (2022)

Analysis of the Potential for N(4)-Hydroxycytidine To Inhibit Mitochondrial Replication and Function
por: Sticher, Zachary M., et al.
Publicado: (2020)

Development and validation of assays for the quantification of β-D-N(4)-hydroxycytidine in human plasma and β-D-N(4)-hydroxycytidine-triphosphate in peripheral blood mononuclear cell lysates
por: Parsons, Teresa L., et al.
Publicado: (2021)

Statistical considerations for dominant lethal mutagenic trials.
por: Salsburg, D S
Publicado: (1973)

Lethal mutagenesis and evolutionary epidemiology
por: Martin, Guillaume, et al.
Publicado: (2010)

Fact and Fiction about 1%: Next Generation Sequencing and the Detection of Minor Drug Resistant Variants in HIV-1 Populations with and without Unique Molecular Identifiers
por: Zhou, Shuntai, et al.
Publicado: (2020)

Lethal mutagenesis of an RNA plant virus via lethal defection
por: Díaz-Martínez, Luis, et al.
Publicado: (2018)

Harnessing mutagenic homologous recombination for targeted mutagenesis in vivo by TaGTEAM
por: Finney-Manchester, Shawn P., et al.
Publicado: (2013)

Cytotoxicity and Mutagenicity of Narrowband UVB to Mammalian Cells
por: Buglewicz, Dylan J., et al.
Publicado: (2020)

Mutation Induced Extinction in Finite Populations: Lethal Mutagenesis and Lethal Isolation
por: Wylie, C. Scott, et al.
Publicado: (2012)

Antifertility effects and dominant lethal assays for mutagenic effects of DEHP.
por: Autian, J
Publicado: (1982)

Empirical Complexities in the Genetic Foundations of Lethal Mutagenesis
por: Bull, James J., et al.
Publicado: (2013)

Rare haplotype load as marker for lethal mutagenesis
por: Gregori, Josep, et al.
Publicado: (2018)

Escape from Human Monoclonal Antibody Neutralization Affects In Vitro and In Vivo Fitness of Severe Acute Respiratory Syndrome Coronavirus
por: Rockx, Barry, et al.
Publicado: (2010)

Base excision repair intermediates are mutagenic in mammalian cells
por: Simonelli, Valeria, et al.
Publicado: (2005)

Sequencing the Biology of Entry: The Retroviral env Gene
por: Swanstrom, Ronald, et al.
Publicado: (2017)

Visceral leishmaniasis lethality in Brazil: an exploratory analysis of associated demographic and socioeconomic factors
por: Donato, Lucas Edel, et al.
Publicado: (2020)

Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir
por: de Ávila, Ana I., et al.
Publicado: (2016)

Evolutionary safety of lethal mutagenesis driven by antiviral treatment
por: Lobinska, Gabriela, et al.
Publicado: (2023)

Thymidine Kinase(+/−) Mammalian Cell Mutagenicity Assays for Assessment of Nanomaterials
por: Chen, Tao, et al.
Publicado: (2022)

Stationary-Phase Mutagenesis in Stressed Bacillus subtilis Cells Operates by Mfd-Dependent Mutagenic Pathways
por: Gómez-Marroquín, Martha, et al.
Publicado: (2016)

Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair
por: Kallimasioti-Pazi, Eirini M., et al.
Publicado: (2018)

Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication
por: Stegmann, Kim M., et al.
Publicado: (2022)

Oxidative DNA Damage by N(4)-hydroxycytidine, a Metabolite of the SARS-CoV-2 Antiviral Molnupiravir
por: Kobayashi, Hatasu, et al.
Publicado: (2022)

Mutagenesis of diploid mammalian genes by gene entrapment
por: Lin, Qing, et al.
Publicado: (2006)

Arenaviruses and Lethal Mutagenesis. Prospects for New Ribavirin-based Interventions
por: Moreno, Héctor, et al.
Publicado: (2012)

Lethal Mutagenesis of Rift Valley Fever Virus Induced by Favipiravir
por: Borrego, Belén, et al.
Publicado: (2019)

Epidemiological profile and lethality of visceral leishmaniasis/human immunodeficiency virus co-infection in an endemic area in Northeast Brazil
por: Machado, Carolina Angélica Libório, et al.
Publicado: (2021)

Oxidative stress induction by crude extract of Xylaria sp. triggers lethality in the larvae of Aedes aegypti (Diptera: Culicidae)
por: Costa, Maria Beatriz Silva, et al.
Publicado: (2022)

Correction: Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair
Publicado: (2019)

Beyond Neutralizing Antibody Levels: The Epitope Specificity of Antibodies Induced by National Institutes of Health Monovalent Dengue Virus Vaccines
por: Swanstrom, Jesica A, et al.
Publicado: (2019)

Does Mutational Robustness Inhibit Extinction by Lethal Mutagenesis in Viral Populations?
por: O'Dea, Eamon B., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ikmq4b8srm20v2vbri93g55s6j