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Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway

BACKGROUND: Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from damaged mitochondria into the cytosol. mtDNA stress may contribute to cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway activation in infectious diseases. Odontoblasts are the first...

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Detalles Bibliográficos
Autores principales:	Zhou, Lu, Zhang, Yi-Fei, Yang, Fu-Hua, Mao, Han-Qing, Chen, Zhi, Zhang, Lu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136190/ https://www.ncbi.nlm.nih.gov/pubmed/34016129 http://dx.doi.org/10.1186/s12964-021-00738-7

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