Cargando…
Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies
Precursor messenger RNA (pre-mRNA) splicing is a fundamental step in eukaryotic gene expression that systematically removes non-coding regions (introns) and ligates coding regions (exons) into a continuous message (mature mRNA). This process is highly regulated and can be highly flexible through a p...
Autores principales: | Li, Dunhui, McIntosh, Craig Stewart, Mastaglia, Frank Louis, Wilton, Steve Donald, Aung-Htut, May Thandar |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136212/ https://www.ncbi.nlm.nih.gov/pubmed/34016162 http://dx.doi.org/10.1186/s40035-021-00240-7 |
Ejemplares similares
-
Correction to: Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies
por: Li, Dunhui, et al.
Publicado: (2021) -
Polyglutamine Ataxias: Our Current Molecular Understanding and What the Future Holds for Antisense Therapies
por: McIntosh, Craig S., et al.
Publicado: (2021) -
Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations
por: Cale, Jessica M., et al.
Publicado: (2023) -
Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing
por: McIntosh, Craig S., et al.
Publicado: (2019) -
Splice correction therapies for familial hypercholesterolemic patients with low-density lipoprotein receptor mutations
por: McIntosh, Craig S., et al.
Publicado: (2021)