IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation

The immunoregulatory enzyme, indoleamine 2,3-dioxygenase (IDO1) and the PD-1/PD-L1 axis are potent mechanisms that impede effective anti-tumor immunity in ovarian cancer. However, whether the IDO pathway regulates PD-1 expression in T cells is currently unknown. Here we show that tumoral IDO1 expres...

Descripción completa

Detalles Bibliográficos
Autores principales: Amobi-McCloud, Adaobi, Muthuswamy, Ravikumar, Battaglia, Sebastiano, Yu, Han, Liu, Tao, Wang, Jianmin, Putluri, Vasanta, Singh, Prashant K., Qian, Feng, Huang, Ruea-Yea, Putluri, Nagireddy, Tsuji, Takemasa, Lugade, Amit A., Liu, Song, Odunsi, Kunle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136272/
https://www.ncbi.nlm.nih.gov/pubmed/34025677
http://dx.doi.org/10.3389/fimmu.2021.678999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136272/
https://www.ncbi.nlm.nih.gov/pubmed/34025677
http://dx.doi.org/10.3389/fimmu.2021.678999

Ejemplares similares