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IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation

The immunoregulatory enzyme, indoleamine 2,3-dioxygenase (IDO1) and the PD-1/PD-L1 axis are potent mechanisms that impede effective anti-tumor immunity in ovarian cancer. However, whether the IDO pathway regulates PD-1 expression in T cells is currently unknown. Here we show that tumoral IDO1 expres...

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Detalles Bibliográficos
Autores principales:	Amobi-McCloud, Adaobi, Muthuswamy, Ravikumar, Battaglia, Sebastiano, Yu, Han, Liu, Tao, Wang, Jianmin, Putluri, Vasanta, Singh, Prashant K., Qian, Feng, Huang, Ruea-Yea, Putluri, Nagireddy, Tsuji, Takemasa, Lugade, Amit A., Liu, Song, Odunsi, Kunle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136272/ https://www.ncbi.nlm.nih.gov/pubmed/34025677 http://dx.doi.org/10.3389/fimmu.2021.678999

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