Compromised MPS1 Activity Induces Multipolar Spindle Formation in Oocytes From Aged Mares: Establishing the Horse as a Natural Animal Model to Study Age-Induced Oocyte Meiotic Spindle Instability

Aneuploidy originating during meiosis in oocytes is the major cause of reduced fertility, implantation failure and miscarriage in women beyond their mid-thirties. Loss of chromosome cohesion, and defective microtubule dynamics and spindle assembly are, in turn, the major contributors to the error-pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Rizzo, Marilena, Stout, Tom A. E., Cristarella, Santo, Quartuccio, Marco, Kops, Geert J. P. L., De Ruijter-Villani, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136435/
https://www.ncbi.nlm.nih.gov/pubmed/34026756
http://dx.doi.org/10.3389/fcell.2021.657366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136435/
https://www.ncbi.nlm.nih.gov/pubmed/34026756
http://dx.doi.org/10.3389/fcell.2021.657366

Ejemplares similares