Preferential CEBP binding to T:G mismatches and increased C-to-T human somatic mutations

DNA cytosine methylation in mammals modulates gene expression and chromatin accessibility. It also impacts mutation rates, via spontaneous oxidative deamination of 5-methylcytosine (5mC) to thymine. In most cases the resulting T:G mismatches are repaired, following T excision by one of the thymine D...

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Detalles Bibliográficos
Autores principales: Yang, Jie, Horton, John R, Akdemir, Kadir C, Li, Jia, Huang, Yun, Kumar, Janani, Blumenthal, Robert M, Zhang, Xing, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136768/
https://www.ncbi.nlm.nih.gov/pubmed/33877329
http://dx.doi.org/10.1093/nar/gkab276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136768/
https://www.ncbi.nlm.nih.gov/pubmed/33877329
http://dx.doi.org/10.1093/nar/gkab276

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