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Untangling the crosstalk between BRCA1 and R-loops during DNA repair

R-loops are RNA:DNA hybrids assembled during biological processes but are also linked to genetic instability when formed out of their natural context. Emerging evidence suggests that the repair of DNA double-strand breaks requires the formation of a transient R-loop, which eventually must be removed...

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Detalles Bibliográficos
Autores principales: San Martin Alonso, Marta, Noordermeer, Sylvie M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136775/
https://www.ncbi.nlm.nih.gov/pubmed/33755171
http://dx.doi.org/10.1093/nar/gkab178