Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction

Activation-induced deaminase (AID) initiates antibody diversification in germinal center B cells by deaminating cytosines, leading to somatic hypermutation and class-switch recombination. Loss-of-function mutations in AID lead to hyper-IgM syndrome type 2 (HIGM2), a rare human primary antibody defic...

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Detalles Bibliográficos
Autores principales: Català-Moll, Francesc, Ferreté-Bonastre, Anna G, Li, Tianlu, Weichenhan, Dieter, Lutsik, Pavlo, Ciudad, Laura, Álvarez-Prado, Ángel F, Rodríguez-Ubreva, Javier, Klemann, Christian, Speckmann, Carsten, Vilas-Zornoza, Amaya, Abolhassani, Hassan, Martínez-Gallo, Mónica, Dieli-Crimi, Romina, Rivière, Jacques G, Martín-Nalda, Andrea, Colobran, Roger, Soler-Palacín, Pere, Kracker, Sven, Hammarström, Lennart, Prosper, Felipe, Durandy, Anne, Grimbacher, Bodo, Plass, Christoph, Ballestar, Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136777/
https://www.ncbi.nlm.nih.gov/pubmed/33950194
http://dx.doi.org/10.1093/nar/gkab322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136777/
https://www.ncbi.nlm.nih.gov/pubmed/33950194
http://dx.doi.org/10.1093/nar/gkab322

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