eIF4E3 forms an active eIF4F complex during stresses (eIF4F(S)) targeting mTOR and re-programs the translatome

The eIF4E are a family of initiation factors that bind the mRNA 5′ cap, regulating the proteome and the cellular phenotype. eIF4E1 mediates global translation and its activity is controlled via the PI3K/AKT/mTOR pathway. mTOR down-regulation results in eIF4E1 sequestration into an inactive complex w...

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Detalles Bibliográficos
Autores principales: Weiss, Benjamin, Allen, George Edward, Kloehn, Joachim, Abid, Karim, Jaquier-Gubler, Pascale, Curran, Joseph Alphonsus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136781/
https://www.ncbi.nlm.nih.gov/pubmed/33893802
http://dx.doi.org/10.1093/nar/gkab267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136781/
https://www.ncbi.nlm.nih.gov/pubmed/33893802
http://dx.doi.org/10.1093/nar/gkab267

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