HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation

DNA ligase 1 (LIG1) is known as the major DNA ligase responsible for Okazaki fragment joining. Recent studies have implicated LIG3 complexed with XRCC1 as an alternative player in Okazaki fragment joining in cases where LIG1 is not functional, although the underlying mechanisms are largely unknown....

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Detalles Bibliográficos
Autores principales: Kumamoto, Soichiro, Nishiyama, Atsuya, Chiba, Yoshie, Miyashita, Ryota, Konishi, Chieko, Azuma, Yoshiaki, Nakanishi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136790/
https://www.ncbi.nlm.nih.gov/pubmed/33872376
http://dx.doi.org/10.1093/nar/gkab269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136790/
https://www.ncbi.nlm.nih.gov/pubmed/33872376
http://dx.doi.org/10.1093/nar/gkab269

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