FreeHi-C simulates high fidelity Hi-C data for benchmarking and data augmentation

Ability to simulate high-throughput chromatin conformation (Hi-C) data is foundational for benchmarking Hi-C data analysis methods. Here we present a non-parametric strategy named FreeHi-C to simulate Hi-C data from the interacting genome fragments. Data from FreeHi-C exhibit high fidelity to biolog...

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Detalles Bibliográficos
Autores principales: Zheng, Ye, Keleş, Sündüz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136837/
https://www.ncbi.nlm.nih.gov/pubmed/31712779
http://dx.doi.org/10.1038/s41592-019-0624-3
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author Zheng, Ye
Keleş, Sündüz
author_facet Zheng, Ye
Keleş, Sündüz
author_sort Zheng, Ye
collection PubMed
description Ability to simulate high-throughput chromatin conformation (Hi-C) data is foundational for benchmarking Hi-C data analysis methods. Here we present a non-parametric strategy named FreeHi-C to simulate Hi-C data from the interacting genome fragments. Data from FreeHi-C exhibit high fidelity to biological Hi-C data. FreeHi-C boosts the precision and power of differential chromatin interaction detection through data augmentation under preserved false discovery rate control.
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spelling pubmed-81368372021-05-20 FreeHi-C simulates high fidelity Hi-C data for benchmarking and data augmentation Zheng, Ye Keleş, Sündüz Nat Methods Article Ability to simulate high-throughput chromatin conformation (Hi-C) data is foundational for benchmarking Hi-C data analysis methods. Here we present a non-parametric strategy named FreeHi-C to simulate Hi-C data from the interacting genome fragments. Data from FreeHi-C exhibit high fidelity to biological Hi-C data. FreeHi-C boosts the precision and power of differential chromatin interaction detection through data augmentation under preserved false discovery rate control. 2019-11-11 2020-01 /pmc/articles/PMC8136837/ /pubmed/31712779 http://dx.doi.org/10.1038/s41592-019-0624-3 Text en http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Zheng, Ye
Keleş, Sündüz
FreeHi-C simulates high fidelity Hi-C data for benchmarking and data augmentation
title FreeHi-C simulates high fidelity Hi-C data for benchmarking and data augmentation
title_full FreeHi-C simulates high fidelity Hi-C data for benchmarking and data augmentation
title_fullStr FreeHi-C simulates high fidelity Hi-C data for benchmarking and data augmentation
title_full_unstemmed FreeHi-C simulates high fidelity Hi-C data for benchmarking and data augmentation
title_short FreeHi-C simulates high fidelity Hi-C data for benchmarking and data augmentation
title_sort freehi-c simulates high fidelity hi-c data for benchmarking and data augmentation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136837/
https://www.ncbi.nlm.nih.gov/pubmed/31712779
http://dx.doi.org/10.1038/s41592-019-0624-3
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