Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

Gene activator proteins comprise distinct DNA-binding and transcriptional activation domains (ADs). Because few ADs have been described, we tested domains tiling all yeast transcription factors for activation in vivo and identified 150 ADs. By mRNA display, we showed that 73% of ADs bound the Med15...

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Detalles Bibliográficos
Autores principales: Sanborn, Adrian L, Yeh, Benjamin T, Feigerle, Jordan T, Hao, Cynthia V, Townshend, Raphael JL, Lieberman Aiden, Erez, Dror, Ron O, Kornberg, Roger D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137143/
https://www.ncbi.nlm.nih.gov/pubmed/33904398
http://dx.doi.org/10.7554/eLife.68068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137143/
https://www.ncbi.nlm.nih.gov/pubmed/33904398
http://dx.doi.org/10.7554/eLife.68068

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