Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells

BACKGROUND: Autologous T cells engineered to express a chimeric antigen receptor (CAR) specific for CD19 molecule have transformed the therapeutic landscape in patients with highly refractory leukemia and lymphoma, and the use of donor-generated allogeneic CAR T is paving the way for further breakth...

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Detalles Bibliográficos
Autores principales: Bai, Zhiliang, Lundh, Stefan, Kim, Dongjoo, Woodhouse, Steven, Barrett, David M, Myers, Regina M, Grupp, Stephan A, Maus, Marcela V, June, Carl H, Camara, Pablo G, Melenhorst, J Joseph, Fan, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137188/
https://www.ncbi.nlm.nih.gov/pubmed/34006631
http://dx.doi.org/10.1136/jitc-2020-002328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137188/
https://www.ncbi.nlm.nih.gov/pubmed/34006631
http://dx.doi.org/10.1136/jitc-2020-002328

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