Cargando…

Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors

BACKGROUND: Pituitary dysfunction is a life-threatening immune-related adverse event (irAE) induced by immune checkpoint inhibitors (ICIs). To date, it is not possible to identify patients who may develop pituitary irAEs prior to ICI treatment. The aim of this study was to characterize the predispos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kobayashi, Tomoko, Iwama, Shintaro, Sugiyama, Daisuke, Yasuda, Yoshinori, Okuji, Takayuki, Ito, Masaaki, Ito, Sachiko, Sugiyama, Mariko, Onoue, Takeshi, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Suga, Hidetaka, Banno, Ryoichi, Nishikawa, Hiroyoshi, Arima, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Immunotherapy Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137231/ https://www.ncbi.nlm.nih.gov/pubmed/34011534 http://dx.doi.org/10.1136/jitc-2021-002493

Ejemplares similares

Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study
por: Kobayashi, Tomoko, et al.
Publicado: (2020)

Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice
por: Ito, Masaaki, et al.
Publicado: (2023)

GABA(B) Receptor Signaling in the Mesolimbic System Suppresses Binge-like Consumption of a High-Fat Diet
por: Tsunekawa, Taku, et al.
Publicado: (2019)

Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice
por: Kawaguchi, Yohei, et al.
Publicado: (2020)

Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia
por: Tsunekawa, Taku, et al.
Publicado: (2017)

Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled trial
por: Wada, Eri, et al.
Publicado: (2020)

SAT-648 Flash Glucose Monitoring Helps Achieve Better Glycemic Control Than Conventional Self-Monitoring of Blood Glucose in Non-Insulin-Treated Type 2 Diabetes: A Randomized Controlled Trial
por: Wada, Eri, et al.
Publicado: (2020)

Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin
por: Ito, Yoshihiro, et al.
Publicado: (2022)

Dipeptidyl peptidase-4 inhibitor anagliptin reduces fasting apolipoprotein B-48 levels in patients with type 2 diabetes: A randomized controlled trial
por: Onoue, Takeshi, et al.
Publicado: (2020)

Dietary sodium chloride attenuates increased β-cell mass to cause glucose intolerance in mice under a high-fat diet
por: Taki, Keigo, et al.
Publicado: (2021)

Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice
por: Mizoguchi, Akira, et al.
Publicado: (2021)

GABA(B) receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice
por: Sun, Runan, et al.
Publicado: (2021)

Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study
por: Handa, Tomoko, et al.
Publicado: (2022)

Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons
por: Miyata, Takashi, et al.
Publicado: (2020)

Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation
por: Taga, Shiori, et al.
Publicado: (2023)

Inflammation in VTA Caused by HFD Induces Activation of Dopaminergic Neurons Accompanied by Binge-like Eating
por: Sun, Runan, et al.
Publicado: (2022)

Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study
por: Okada, Norio, et al.
Publicado: (2020)

Generation of hypothalamic neural stem cell-like cells in vitro from human pluripotent stem cells
por: Miwata, Tsutomu, et al.
Publicado: (2023)

Impact of immune-related adverse events on the therapeutic efficacy of pembrolizumab in urothelial carcinoma: a multicenter retrospective study using time-dependent analysis
por: Kawai, Taketo, et al.
Publicado: (2022)

Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state
por: Ozaki, Hajime, et al.
Publicado: (2022)

Glucose-6-phosphate dehydrogenase correlates with tumor immune activity and programmed death ligand-1 expression in Merkel cell carcinoma
por: Nakamura, Motoki, et al.
Publicado: (2020)

TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment
por: Kawashima, Shusuke, et al.
Publicado: (2021)

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study
por: Kobayashi, Tomoko, et al.
Publicado: (2018)

Induction of Functional Hypothalamus and Pituitary Tissues From Pluripotent Stem Cells for Regenerative Medicine
por: Kano, Mayuko, et al.
Publicado: (2020)

Disease Modeling of Pituitary Adenoma Using Human Pluripotent Stem Cells
por: Matsumoto, Ryusaku, et al.
Publicado: (2022)

Impact of C-reactive protein flare-response on oncological outcomes in patients with metastatic renal cell carcinoma treated with nivolumab
por: Fukuda, Shohei, et al.
Publicado: (2021)

SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response
por: Tanagala, Kranthi Kiran Kishore, et al.
Publicado: (2022)

Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment
por: Väyrynen, Juha P, et al.
Publicado: (2021)

Comparison of SP263 and 22C3 immunohistochemistry PD-L1 assays for clinical efficacy of adjuvant atezolizumab in non-small cell lung cancer: results from the randomized phase III IMpower010 trial
por: Zhou, Caicun, et al.
Publicado: (2023)

SUN-062 Randomized Controlled Trial for Assessment of the Effects of Anaglipitin, a DPP-4 Inhibitor, on Blood Lipids in Type 2 Diabetic Patients
por: Onoue, Takeshi, et al.
Publicado: (2019)

Distinctive germline expression of class I human leukocyte antigen (HLA) alleles and DRB1 heterozygosis predict the outcome of patients with non-small cell lung cancer receiving PD-1/PD-L1 immune checkpoint blockade
por: Correale, Pierpaolo, et al.
Publicado: (2020)

EpCAM Is a Surface Marker for Enriching Anterior Pituitary Cells From Human Hypothalamic-Pituitary Organoids
por: Kodani, Yu, et al.
Publicado: (2022)

Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC
por: Keegan, Alissa, et al.
Publicado: (2020)

Clinical, FDG-PET and molecular markers of immune checkpoint inhibitor response in patients with metastatic Merkel cell carcinoma
por: Weppler, Alison M, et al.
Publicado: (2020)

Gene signature of antigen processing and presentation machinery predicts response to checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma
por: Thompson, Jeffrey C, et al.
Publicado: (2020)

Novel, non-invasive imaging approach to identify patients with advanced non-small cell lung cancer at risk of hyperprogressive disease with immune checkpoint blockade
por: Vaidya, Pranjal, et al.
Publicado: (2020)

KALRN mutations promote antitumor immunity and immunotherapy response in cancer
por: Li, Mengyuan, et al.
Publicado: (2020)

Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma
por: Liu, Fangming, et al.
Publicado: (2020)

Development and validation of a genomic mutation signature to predict response to PD-1 inhibitors in non-squamous NSCLC: a multicohort study
por: Bai, Xue, et al.
Publicado: (2020)

Predicting response to immunotherapy in advanced non-small-cell lung cancer using tumor mutational burden radiomic biomarker
por: He, Bingxi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_43jaqqgdf5rc9um0hj8hmk678j