Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy

BACKGROUND/AIMS: Metabolic syndrome has been reported to be a risk factor for metachronous colorectal neoplasia (CRN). However, the impact of nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, on the development of metachronous CRN after polypectomy has been rar...

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Autores principales: Kim, Nam Hee, Jung, Yoon Suk, Park, Jung Ho, Park, Dong Il, Sohn, Chong Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137416/
https://www.ncbi.nlm.nih.gov/pubmed/32630984
http://dx.doi.org/10.3904/kjim.2019.360
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author Kim, Nam Hee
Jung, Yoon Suk
Park, Jung Ho
Park, Dong Il
Sohn, Chong Il
author_facet Kim, Nam Hee
Jung, Yoon Suk
Park, Jung Ho
Park, Dong Il
Sohn, Chong Il
author_sort Kim, Nam Hee
collection PubMed
description BACKGROUND/AIMS: Metabolic syndrome has been reported to be a risk factor for metachronous colorectal neoplasia (CRN). However, the impact of nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, on the development of metachronous CRN after polypectomy has been rarely examined. We evaluated the association between NAFLD and the development of metachronous CRN after polypectomy. METHODS: Asymptomatic subjects who underwent abdominal ultrasonography and endoscopic removal of ≥ 1 adenomas at the index colonoscopy between 2010 and 2014, and had a follow-up surveillance colonoscopy until 2017 were analyzed. RESULTS: Of 6,182 participants, 2,642 (42.7%) had NAFLD at the time of the index colonoscopy. Patients with NAFLD had significantly higher cumulative incidence rates of metachronous overall CRN than those without NAFLD in both men (19.4% vs. 18.2% at 3 years and 49.2% vs. 44.0% at 5 years; p = 0.001) and women (18.7% vs. 10.5% at 3 years and 56.1% vs. 29.8% at 5 years; p < 0.001). Even after adjusting for confounders, NAFLD remained independently associated with an increased risk of metachronous overall CRN in both men (adjusted hazard ratio [HR], 1.17; 95% confidence interval [CI], 1.06 to 1.29) and women (adjusted HR, 1.63; 95% CI, 1.27 to 2.07). Additionally, NAFLD was an independent risk factor for metachronous advanced CRN (ACRN) in women (adjusted HR, 2.61; 95% CI, 1.27 to 5.37). CONCLUSIONS: NAFLD is related to an increased risk of metachronous CRN after polypectomy. Especially, women with NAFLD are at an increased risk of developing metachronous ACRN. Our results indicate a possible effect of NAFLD on the pathogenesis of CRN.
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spelling pubmed-81374162021-05-28 Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy Kim, Nam Hee Jung, Yoon Suk Park, Jung Ho Park, Dong Il Sohn, Chong Il Korean J Intern Med Original Article BACKGROUND/AIMS: Metabolic syndrome has been reported to be a risk factor for metachronous colorectal neoplasia (CRN). However, the impact of nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, on the development of metachronous CRN after polypectomy has been rarely examined. We evaluated the association between NAFLD and the development of metachronous CRN after polypectomy. METHODS: Asymptomatic subjects who underwent abdominal ultrasonography and endoscopic removal of ≥ 1 adenomas at the index colonoscopy between 2010 and 2014, and had a follow-up surveillance colonoscopy until 2017 were analyzed. RESULTS: Of 6,182 participants, 2,642 (42.7%) had NAFLD at the time of the index colonoscopy. Patients with NAFLD had significantly higher cumulative incidence rates of metachronous overall CRN than those without NAFLD in both men (19.4% vs. 18.2% at 3 years and 49.2% vs. 44.0% at 5 years; p = 0.001) and women (18.7% vs. 10.5% at 3 years and 56.1% vs. 29.8% at 5 years; p < 0.001). Even after adjusting for confounders, NAFLD remained independently associated with an increased risk of metachronous overall CRN in both men (adjusted hazard ratio [HR], 1.17; 95% confidence interval [CI], 1.06 to 1.29) and women (adjusted HR, 1.63; 95% CI, 1.27 to 2.07). Additionally, NAFLD was an independent risk factor for metachronous advanced CRN (ACRN) in women (adjusted HR, 2.61; 95% CI, 1.27 to 5.37). CONCLUSIONS: NAFLD is related to an increased risk of metachronous CRN after polypectomy. Especially, women with NAFLD are at an increased risk of developing metachronous ACRN. Our results indicate a possible effect of NAFLD on the pathogenesis of CRN. The Korean Association of Internal Medicine 2021-05 2020-07-07 /pmc/articles/PMC8137416/ /pubmed/32630984 http://dx.doi.org/10.3904/kjim.2019.360 Text en Copyright © 2021 The Korean Association of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Nam Hee
Jung, Yoon Suk
Park, Jung Ho
Park, Dong Il
Sohn, Chong Il
Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
title Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
title_full Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
title_fullStr Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
title_full_unstemmed Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
title_short Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
title_sort impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137416/
https://www.ncbi.nlm.nih.gov/pubmed/32630984
http://dx.doi.org/10.3904/kjim.2019.360
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