Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells

Hypoxia, angiogenesis, and immunosuppression have been proposed to be interrelated events that fuel tumor progression and impair the clinical effectiveness of anti-tumor therapies. Here we present new mechanistic data highlighting the role of hypoxia in fine-tuning CD8 T cell exhaustion in vitro, in...

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Detalles Bibliográficos
Autores principales: Bannoud, Nadia, Dalotto-Moreno, Tomás, Kindgard, Lucía, García, Pablo A., Blidner, Ada G., Mariño, Karina V., Rabinovich, Gabriel A., Croci, Diego O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137905/
https://www.ncbi.nlm.nih.gov/pubmed/34025660
http://dx.doi.org/10.3389/fimmu.2021.660944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137905/
https://www.ncbi.nlm.nih.gov/pubmed/34025660
http://dx.doi.org/10.3389/fimmu.2021.660944

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