High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer

Chromatin accessibility profiling can identify putative regulatory regions genome wide; however, pooled single-cell methods for assessing the effects of regulatory perturbations on accessibility are limited. Here, we report a modified droplet-based single-cell ATAC-seq protocol for perturbing and ev...

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Detalles Bibliográficos
Autores principales: Pierce, Sarah E., Granja, Jeffrey M., Greenleaf, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137922/
https://www.ncbi.nlm.nih.gov/pubmed/34016988
http://dx.doi.org/10.1038/s41467-021-23213-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137922/
https://www.ncbi.nlm.nih.gov/pubmed/34016988
http://dx.doi.org/10.1038/s41467-021-23213-w

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