Cargando…

Epithelial-mesenchymal transition sensitizes breast cancer cells to cell death via the fungus-derived sesterterpenoid ophiobolin A

The epithelial–mesenchymal transition (EMT) imparts properties of cancer stem-like cells, including resistance to frequently used chemotherapies, necessitating the identification of molecules that induce cell death specifically in stem-like cells with EMT properties. Herein, we demonstrate that brea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reisenauer, Keighley N., Tao, Yongfeng, Das, Provas, Song, Shuxuan, Svatek, Haleigh, Patel, Saawan D., Mikhail, Sheridan, Ingros, Alec, Sheesley, Peter, Masi, Marco, Boari, Angela, Evidente, Antonio, Kornienko, Alexander, Romo, Daniel, Taube, Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137940/ https://www.ncbi.nlm.nih.gov/pubmed/34017048 http://dx.doi.org/10.1038/s41598-021-89923-9

Ejemplares similares

The Biological Activities of Sesterterpenoid-Type Ophiobolins
por: Tian, Wei, et al.
Publicado: (2017)

Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets
por: Maslivetc, Vladimir, et al.
Publicado: (2021)

Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity
por: Bury, M, et al.
Publicado: (2013)

New Ophiobolin Derivatives from the Marine Fungus Aspergillus flocculosus and Their Cytotoxicities against Cancer Cells
por: Choi, Byeoung-Kyu, et al.
Publicado: (2019)

Ophiobolin A, a sesterpenoid fungal phytotoxin, displays different mechanisms of cell death in mammalian cells depending upon the cancer cell origin
por: Morrison, Rachel, et al.
Publicado: (2017)

Sesterterpene ophiobolin biosynthesis involving multiple gene clusters in Aspergillus ustus
por: Chai, Hangzhen, et al.
Publicado: (2016)

Research Progress on Fungal Sesterterpenoids Biosynthesis
por: Zhang, Ping, et al.
Publicado: (2022)

The Biosynthesis and Transport of Ophiobolins in Aspergillus ustus 094102
por: Yan, Jingjing, et al.
Publicado: (2022)

Characterization and phytotoxicity of ophiobolins produced by Bipolaris setariae
por: Zhao, Xing-Li, et al.
Publicado: (2021)

New Ophiobolins from the Deep-Sea Derived Fungus Aspergillus sp. WHU0154 and Their Anti-Inflammatory Effects
por: Ding, Wenjuan, et al.
Publicado: (2020)

Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.
por: Chang, Yu-Chia, et al.
Publicado: (2012)

Targeting cancer with sesterterpenoids: the new potential antitumor drugs
por: Zhang, Caiguo, et al.
Publicado: (2015)

Synthesis of Bioconjugate Sesterterpenoids with Phospholipids and Polyunsaturated Fatty Acids
por: Gil-Mesón, Ana, et al.
Publicado: (2015)

Regulating Methylation at H3K27: A Trick or Treat for Cancer Cell Plasticity
por: Das, Provas, et al.
Publicado: (2020)

Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
por: Lee, Yeon-Ju, et al.
Publicado: (2014)

New Scalarane Sesterterpenoids from the Formosan Sponge Ircinia felix
por: Lai, Ya-Yuan, et al.
Publicado: (2015)

Ophiobolin A Induces Autophagy and Activates the Mitochondrial Pathway of Apoptosis in Human Melanoma Cells
por: Rodolfo, Carlo, et al.
Publicado: (2016)

Chemical analysis and anticancer activity of sesterterpenoid from an endophytic fungus Hypomontagnella monticulosa Zg15SU and its host Zingiber griffithii Baker
por: Lutfia, Anisa, et al.
Publicado: (2021)

New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix
por: Lai, Ya-Yuan, et al.
Publicado: (2015)

Scalarane Sesterterpenoids Isolated from the Marine Sponge Hyrtios erectus and their Cytotoxicity
por: Tran, Huynh Nguyen Khanh, et al.
Publicado: (2022)

(2S,3R,4S,4aR)-2,3,4,7-Tetrahydroxy-3,4,4a,5-tetrahydro[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one hemihydrate
por: Jucov, Evgheni, et al.
Publicado: (2012)

In Vitro Effects of Fungal Phytotoxins on Cancer Cell Viability: First Insight into Structure Activity Relationship of a Potent Metabolite of Cochliobolus australiensis Radicinin
por: Mathieu, Veronique, et al.
Publicado: (2022)

The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine
por: Chidley, Christopher, et al.
Publicado: (2016)

Ophiobolin A Covalently Targets Complex IV Leading to Mitochondrial Metabolic Collapse in Cancer Cells
por: Gowans, Flor A., et al.
Publicado: (2023)

Scalarane Sesterterpenoids with Antibacterial and Anti-Proliferative Activities from the Mushroom Neonothopanus nambi
por: Wisetsai, Awat, et al.
Publicado: (2021)

Bio-Activity and Dereplication-Based Discovery of Ophiobolins and Other Fungal Secondary Metabolites Targeting Leukemia Cells
por: Bladt, Tanja Thorskov, et al.
Publicado: (2013)

Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge Scalarispongia sp.
por: Lee, Yeon-Ju, et al.
Publicado: (2019)

Unprecedented sesterterpenoids, orientanoids A–C: discovery, bioinspired total synthesis and antitumor immunity
por: Zheng, Cheng-Yu, et al.
Publicado: (2023)

Cacospongionolide and Scalaradial, Two Marine Sesterterpenoids as Potent Apoptosis-Inducing Factors in Human Carcinoma Cell Lines
por: De Stefano, Daniela, et al.
Publicado: (2012)

Inuloxin E, a New Seco-Eudesmanolide Isolated from Dittrichia viscosa, Stimulating Orobanche cumana Seed Germination
por: Masi, Marco, et al.
Publicado: (2019)

Araufuranone: A New Phytotoxic Tetrasubstituted Dihydrofuro[3,2-b]furan-2(5H)-One Isolated from Ascochyta araujiae
por: Masi, Marco, et al.
Publicado: (2022)

Correction: Masi et al. Araufuranone: A New Phytotoxic Tetrasubstituted Dihydrofuro[3,2-b]furan-2(5H)-One Isolated from Ascochyta araujiae. Biomolecules 2022, 12, 1274
por: Masi, Marco, et al.
Publicado: (2023)

Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis
por: Kim, In Young, et al.
Publicado: (2017)

Arabidopsis Defense against the Pathogenic Fungus Drechslera gigantea Is Dependent on the Integrity of the Unfolded Protein Response
por: Samperna, Simone, et al.
Publicado: (2021)

Scalarane-Type Sesterterpenoids from the Marine Sponge Lendenfeldia sp. Alleviate Inflammation in Human Neutrophils
por: Peng, Bo-Rong, et al.
Publicado: (2021)

Novel Topologically Complex Scaffold Derived from Alkaloid Haemanthamine
por: Govindaraju, Karthik, et al.
Publicado: (2018)

DFT Study on the Biosynthesis of Verrucosane Diterpenoids and Mangicol Sesterterpenoids: Involvement of Secondary-Carbocation-Free Reaction Cascades
por: Sato, Hajime, et al.
Publicado: (2021)

Ophiobolin A from Bipolaris oryzae Perturbs Motility and Membrane Integrities of Porcine Sperm and Induces Cell Death on Mammalian Somatic Cell Lines
por: Bencsik, Ottó, et al.
Publicado: (2014)

New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism
por: Mirzania, Foroogh, et al.
Publicado: (2022)

Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells
por: Park, Hyun Bong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_7tempnpfcc3ibto8o0rmito2n6