Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1

Organic cation transporter 1 (OCT1, SLC22A1) is localized in the sinusoidal membrane of human hepatocytes and mediates hepatic uptake of weakly basic or cationic drugs and endogenous compounds. Common amino acid substitutions in OCT1 were associated with altered pharmacokinetics and efficacy of drug...

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Detalles Bibliográficos
Autores principales: Römer, Sarah, Meyer, Marleen J., Klein, Kathrin, Schneider, Lennart V., Matthaei, Johannes, Tzvetkova, Ana, Łapczuk-Romańska, Joanna, Gaedcke, Jochen, Droździk, Marek, Brockmöller, Jürgen, Nies, Anne T., Tzvetkov, Mladen V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137991/
https://www.ncbi.nlm.nih.gov/pubmed/34025422
http://dx.doi.org/10.3389/fphar.2021.661480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137991/
https://www.ncbi.nlm.nih.gov/pubmed/34025422
http://dx.doi.org/10.3389/fphar.2021.661480

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