An Entire Process Optimization Strategy for Comprehensive In Vivo Metabolite Profiling of Prucalopride in Rats Based on Ultra-Performance Liquid Chromatography With Q-Exactive Hybrid Quadrupole–Orbitrap High-Resolution Mass Spectrometry

Prucalopride was widely used for chronic constipation, which is difficult to be adequately relieved by laxatives in adult patients in clinic. Due to the difficulty in metabolite identification, metabolic process of prucalopride had not been investigated in vivo. In this study, an efficient strategy...

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Detalles Bibliográficos
Autores principales: Zuo, Lihua, Liu, Liwei, Yang, Yantao, Yang, Jie, Chen, Min, Zhang, Huafeng, Kang, Jian, Zhang, Xiaojian, Wang, Jiabo, Sun, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138455/
https://www.ncbi.nlm.nih.gov/pubmed/34025397
http://dx.doi.org/10.3389/fphar.2021.610226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138455/
https://www.ncbi.nlm.nih.gov/pubmed/34025397
http://dx.doi.org/10.3389/fphar.2021.610226

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