Cargando…

Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma

BACKGROUND: Cutaneous squamous cell carcinomas (cSCC) are among the most common and highly mutated human malignancies. Understanding the impact of DNA methylation in cSCC may provide avenues for new therapeutic strategies. METHODS: We used reduced-representation bisulfite sequencing for DNA methylat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roth, Kevin, Coussement, Louis, Knatko, Elena V., Higgins, Maureen, Steyaert, Sandra, Proby, Charlotte M., de Meyer, Tim, Dinkova-Kostova, Albena T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138604/ https://www.ncbi.nlm.nih.gov/pubmed/34000624 http://dx.doi.org/10.1016/j.ebiom.2021.103383

Ejemplares similares

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma
por: Knatko, Elena V., et al.
Publicado: (2016)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
por: Kalin, Jay H., et al.
Publicado: (2019)

Pirin, an Nrf2-Regulated Protein, Is Overexpressed in Human Colorectal Tumors
por: Zhang, Ying, et al.
Publicado: (2022)

Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
por: Knatko, Elena V., et al.
Publicado: (2021)

The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response
por: Dinkova-Kostova, Albena T.
Publicado: (2012)

The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2021)

NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis
por: Kahremany, Shirin, et al.
Publicado: (2022)

Downregulation of Keap1 Confers Features of a Fasted Metabolic State
por: Knatko, Elena V., et al.
Publicado: (2020)

The emerging role of Nrf2 in mitochondrial function
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2015)

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2020)

Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety
por: Soliman, Aiten M., et al.
Publicado: (2020)

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action
por: Kostov, Rumen V., et al.
Publicado: (2015)

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives
por: Ghorab, Mostafa M, et al.
Publicado: (2016)

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants()
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2017)

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis
por: Robertson, Holly, et al.
Publicado: (2020)

Nrf2 in TIME: The Emerging Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Tumor Immune Microenvironment
por: Feng, Jialin, et al.
Publicado: (2023)

His Excellency Mr Filipe Nyusi President, Republic of Mozambique
por: Ordan, Julien Marius
Publicado: (2018)

β-carboline alkaloids from Trigonostemon filipes and Trigonostemon lii
por: Li, Shi-Fei, et al.
Publicado: (2012)

Monitoring Keap1–Nrf2 interactions in single live cells
por: Baird, Liam, et al.
Publicado: (2014)

The multifaceted role of Nrf2 in mitochondrial function
por: Holmström, Kira M., et al.
Publicado: (2016)

The role of Nrf2 signaling in counteracting neurodegenerative diseases
por: Dinkova‐Kostova, Albena T., et al.
Publicado: (2018)

The Triterpenoid Nrf2 Activator, CDDO-Me, Decreases Neutrophil Senescence in a Murine Model of Joint Damage
por: Amirova, Kristiana M., et al.
Publicado: (2023)

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production
por: Cvetko, Filip, et al.
Publicado: (2020)

The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2015)

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
por: Yagishita, Yoko, et al.
Publicado: (2019)

Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2022)

Association Analysis Between FILIP1 Polymorphisms and Aspirin Hypersensitivity in Korean Asthmatics
por: Kim, Jason Yongha, et al.
Publicado: (2013)

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2017)

Sensitivity to TOP2 Targeting Chemotherapeutics Is Regulated by Oct1 and FILIP1L
por: Lu, Huarui, et al.
Publicado: (2012)

Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70
por: Yagi, Hideshi, et al.
Publicado: (2017)

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity
por: Casares, Laura, et al.
Publicado: (2020)

Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2018)

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells
por: Roubalová, Lenka, et al.
Publicado: (2017)

NRF2 as an Emerging Therapeutic Target
por: Copple, Ian M., et al.
Publicado: (2017)

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner
por: Zhang, Ying, et al.
Publicado: (2021)

DIA label-free proteomic analysis of murine bone-marrow-derived macrophages
por: Baker, Christa P., et al.
Publicado: (2022)

Transcription factors NRF2 and HSF1 have opposing functions in autophagy
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2017)

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy—Mitochondria, Calcium Dynamics and Reactive Oxygen Species
por: Kovac, Stjepana, et al.
Publicado: (2017)

The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis
por: Henderson, John, et al.
Publicado: (2021)

Editorial: Lignans: Insights Into Their Biosynthesis, Metabolic Engineering, Analytical Methods and Health Benefits
por: Hano, Christophe F., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ra9n81g1d473b9ba12mlb4nkf7