Molecular conformations and dynamics of nucleotide repeats associated with neurodegenerative diseases: double helices and CAG hairpin loops

Pathogenic DNA secondary structures have been identified as a common and causative factor for expansion in trinucleotide, hexanucleotide, and other simple sequence repeats. These expansions underlie about fifty neurological and neuromuscular disorders known as “anticipation diseases”. Cell toxicity...

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Detalles Bibliográficos
Autores principales: Pan, Feng, Zhang, Yuan, Xu, Pengning, Man, Viet Hoang, Roland, Christopher, Weninger, Keith, Sagui, Celeste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138726/
https://www.ncbi.nlm.nih.gov/pubmed/34093995
http://dx.doi.org/10.1016/j.csbj.2021.04.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138726/
https://www.ncbi.nlm.nih.gov/pubmed/34093995
http://dx.doi.org/10.1016/j.csbj.2021.04.037

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