In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration

Fluorescent staining of newly transcribed RNA via metabolic labelling with 5-ethynyluridine (EU) and click chemistry enables visualisation of changes in transcription, such as in conditions of cellular stress. Here, we tested whether EU labelling can be used to examine transcription in vivo in mouse...

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Detalles Bibliográficos
Autores principales: van’t Sant, Lisanne J., White, Joshua J., Hoeijmakers, Jan H. J., Vermeij, Wilbert P., Jaarsma, Dick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139001/
https://www.ncbi.nlm.nih.gov/pubmed/34020718
http://dx.doi.org/10.1186/s40478-021-01200-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139001/
https://www.ncbi.nlm.nih.gov/pubmed/34020718
http://dx.doi.org/10.1186/s40478-021-01200-y

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